ON 146040
CAS No. 1404231-34-0
ON 146040 ( ZINC211117138 )
Catalog No. M26350 CAS No. 1404231-34-0
ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 132 | Get Quote |
|
5MG | 222 | Get Quote |
|
10MG | 357 | Get Quote |
|
25MG | 587 | Get Quote |
|
50MG | 822 | Get Quote |
|
100MG | 1107 | Get Quote |
|
500MG | 2214 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameON 146040
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NoteResearch use only, not for human use.
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Brief DescriptionON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.
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DescriptionON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.(In Vitro):ON 146040 inhibits Abl1 and several mutant versions of this kinase with IC50 150 nM. ON 146040 is highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1000 nM range.?ON 146040 downregulates the phosphorylation of STAT3 and STAT5 in leukemia and myeloma cells.
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SynonymsZINC211117138
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorCB1
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Research Area——
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Indication——
Chemical Information
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CAS Number1404231-34-0
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Formula Weight489.6
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Molecular FormulaC24H23N7O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1CCN(CC1)c1ccc(Nc2ncc3NC(=O)\C(Sc3n2)=C\c2ccc(cc2)[N+]([O-])=O)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Molecular analysis of genetic fidelity in Cannabis sativa L. plants grown from synthetic (encapsulated) seeds following in vitro storage. Biotechnology Letters, 2011, 33(12):2503-2508.
molnova catalog
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